RAF Typhoon FGR4s have joined forces with France's air force in a coordinated attack against an subterranean weapons facility in Syrian territory employed by the IS group, as stated by the British defence ministry.
The location, identified by intelligence, was believed to be housing weapons and explosive materials, the statement said, and was situated in mountains just north of the ancient city of Palmyra in central Syria.
"The RAF jets utilized laser-guided Paveway IV weapons to hit a several approach shafts down to the facility... initial indications suggest the target was engaged successfully," the ministry announced.
There was no evidence of any civilian casualties in the attack on Saturday evening and every plane involved returned safely, the defence officials confirmed.
The British jets were supported by a Voyager aerial refuelling aircraft.
The Islamic State group - also known as Daesh - established militant control over parts of Iraq and Syria before its territorial defeat in 2019.
"This operation shows the UK's leading role, and resolve to operate in unison with our allies, to eradicate any resurgence of the terrorist group and their dangerous and violent ideologies in the area," UK Defence Secretary John Healey stated.
British military aircraft have performed surveillance missions over Syria to "prevent any efforts to regroup" of Islamic State after its military defeat at the battle of Baghuz in 2019, the MoD reported.
"I extend gratitude to the personnel of the UK armed forces who took part in this strike for their professionalism and their courage," Healey commented. "Including them were numerous UK service members on duty over the holidays. This mission, to take out militants who endanger our safety, shows how British military are always on standby, continuously, ensuring Britain's security at home and powerful internationally."
During December, the United States armed forces conducted what it described as a "major assault" on Daesh sites in Syria, after an ambush killed two American soldiers and a civilian linguist in Palmyra.
The United Nations reports IS still boasts between 5,000 and 7,000 fighters in both countries.